(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

Base Information

Chemical Name:(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid
CAS No.:88455-00-9
Molecular Formula:C₃₀H₄₀O₁₂
Molecular Weight:592.64
Hs Code.:

Synonyms:(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

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Chemical Property of (2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

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Technology Process of (2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

There total 5 articles about (2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 88454-99-3
(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

: 88455-00-9
(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 4h; Heating;
DOI:10.1021/jo00179a004

Reference yield:

: 88454-97-1
(7S,8S)-7,8-bis((benzyloxy)methyl)-1,14-dichloro-3,6,9,12-tetraoxatetradecane

: 88455-00-9
(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaI / acetone; methanol / 14 h / Heating

2: 1.) TlOEt / DMF, 1.) roomtemp., 1/2 h, 2.) 60 deg C, 16 h

3: 68 percent / HCl / dioxane; H₂O / 4 h / Heating

With hydrogenchloride; thallium (I) ethoxide; sodium iodide; In 1,4-dioxane; methanol; water; acetone;
DOI:10.1021/jo00179a004

Reference yield:

: 88454-98-2
(7S,8S)-7,8-bis((benzyloxy)methyl)-1,14-diiodo-3,6,9,12-tetraoxatetradecane

: 88455-00-9
(2R,3R,11S,12S)-11,12-Bis-benzyloxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TlOEt / DMF, 1.) roomtemp., 1/2 h, 2.) 60 deg C, 16 h

2: 68 percent / HCl / dioxane; H₂O / 4 h / Heating

With hydrogenchloride; thallium (I) ethoxide; In 1,4-dioxane; water;
DOI:10.1021/jo00179a004