2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

Base Information

Chemical Name:2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester
CAS No.:186258-88-8
Molecular Formula:C₂₁H₃₀O₆
Molecular Weight:378.466
Hs Code.:

Synonyms:2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

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Chemical Property of 2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

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Technology Process of 2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

There total 2 articles about 2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3196-15-4,69043-96-5
Methyl 2-bromobutyrate

: 186258-71-9
(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-ol

: 186258-88-8
2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4039(96)02233-2

Reference yield:

: 34164-50-6
4-penten-1-ylmagnesium bromide

: 186258-88-8
2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) zinc(II) chloride; 2.) CF₃CO₂H; 3.) CSA / 1.) Et₂O, -90 deg C; 2.) TFH/H₂O, reflux; 3.) DMF, 80 deg C

2: 83 percent / NaH / dimethylformamide / Ambient temperature

With camphor-10-sulfonic acid; sodium hydride; trifluoroacetic acid; zinc(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)02233-2

Reference yield:

: 186258-88-8
2-[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-pent-4-enyl-[1,3]dioxan-5-yloxy]-butyric acid methyl ester

: (Z)-(2R,4aR,6R,11aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,10,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononene

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminum hydride / diethyl ether / Heating

2: SO₃*pyr, Et₃N / dimethylsulfoxide; CH₂Cl₂ / Ambient temperature

3: n-BuLi / tetrahydrofuran / Ambient temperature

4: 14 percent / molybdenum complex / benzene / 60 °C

With lithium aluminium tetrahydride; n-butyllithium; pyridine-SO₃ complex; triethylamine; molybdenum; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(96)02233-2