Technology Process of (3S,4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-phenylsulfanyl-hept-1-en-4-ol
There total 4 articles about (3S,4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-phenylsulfanyl-hept-1-en-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
thiophenol;
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 23 ℃;
for 1h;
(3R,4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-chloro-hept-1-en-4-ol;
In
N,N-dimethyl-formamide;
at 0 - 23 ℃;
DOI:10.1002/chem.200500160
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 98 percent / imidazole / 2-methyl-propan-2-ol / 4 h / 23 °C
2.1: O3 / CH2Cl2 / 0.08 h / -78 °C
2.2: 94 percent / PPh3 / CH2Cl2 / 2 h / 23 °C
3.1: 68 percent / LiNc-Hex; IpcBOMe; BF3*Et2O / 4 h / -95 °C
4.1: t-BuOK / 1 h / 23 °C
4.2: 86 percent / dimethylformamide / 0 - 23 °C
With
1H-imidazole; Ipc2B(OMe); LiNc-Hex; boron trifluoride diethyl etherate; potassium tert-butylate; ozone;
In
dichloromethane; tert-butyl alcohol;
3.1: Brown allylation;
DOI:10.1002/anie.200454108
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: O3 / CH2Cl2 / 0.08 h / -78 °C
1.2: 94 percent / PPh3 / CH2Cl2 / 2 h / 23 °C
2.1: 68 percent / LiNc-Hex; IpcBOMe; BF3*Et2O / 4 h / -95 °C
3.1: t-BuOK / 1 h / 23 °C
3.2: 86 percent / dimethylformamide / 0 - 23 °C
With
Ipc2B(OMe); LiNc-Hex; boron trifluoride diethyl etherate; potassium tert-butylate; ozone;
In
dichloromethane;
2.1: Brown allylation;
DOI:10.1002/anie.200454108
