4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

Base Information

• Chemical Name: 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole
• CAS No.: 1163733-27-4
• Molecular Formula: C₁₉H₂₂N₂O₄
• Molecular Weight: 342.395

Synonyms:4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

Chemical Property of 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

Chemical Property:

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Technology Process of 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

There total 2 articles about 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

(E)-3-(2, 4-dimethoxyphenyl)-1-(3, 4-dimethoxyphenyl) prop-2-en-1-one (100753-41-1) → 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-27-4)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2008.07.008

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; sodium hydroxide; In ethanol; 1: Claisen Schmidt condensation;

DOI:10.1002/ardp.201100471

Reference yield: 92.5%

4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-27-4) + 2-Bromoacetyl bromide (598-21-0) → 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-32-1)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 26.5h;

DOI:10.1016/j.ejmech.2008.07.008

upstream raw materials:

(E)-3-(2, 4-dimethoxyphenyl)-1-(3, 4-dimethoxyphenyl) prop-2-en-1-one

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

1-(2-bromopropionyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

1-(3,4,5-trimethoxybenzoyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

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