1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

Base Information

• Chemical Name: 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole
• CAS No.: 1163733-32-1
• Molecular Formula: C₂₁H₂₃BrN₂O₅
• Molecular Weight: 463.328

Synonyms:1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

Chemical Property of 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

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Technology Process of 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

There total 1 articles about 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-27-4) + 2-Bromoacetyl bromide (598-21-0) → 1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-32-1)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 26.5h;

DOI:10.1016/j.ejmech.2008.07.008

Reference yield: 71.3%

1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-32-1) + p-aminobenzophenone (99-92-3) → 1-[2-(4-acetylphenylamino)acetyl]-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-47-8)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.ejmech.2008.07.008

Reference yield: 65.8%

1-(2-bromoacetyl)-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole (1163733-32-1) → 4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1-(2-nitrooxyacetyl)-1H-pyrazole (1163733-40-1)

Guidance literature:

With silver nitrate; In acetonitrile; at 80 ℃;

DOI:10.1016/j.ejmech.2008.07.008

upstream raw materials:

4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

2-Bromoacetyl bromide

Downstream raw materials:

4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1-(2-nitrooxyacetyl)-1H-pyrazole

1-[2-(4-acetylphenylamino)acetyl]-4,5-dihydro-5-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrazole

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