tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate

Base Information

• Chemical Name: tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate
• CAS No.: 1141475-62-8
• Molecular Formula: C₃₁H₃₄FN₃O₄
• Molecular Weight: 531.627
• Mol file: 1141475-62-8.mol

Synonyms:tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate

Chemical Property of tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate

There total 9 articles about tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(bromomethyl)-4-fluorobenzonitrile (856935-35-8) → tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate (1141475-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / 20 °C

2: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

3: coupling reagent / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; acetonitrile;

DOI:10.1002/cmdc.201402557

Reference yield:

C15H19FN2O2 → tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate (1141475-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

2: coupling reagent / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; In ethanol; water; acetonitrile;

DOI:10.1002/cmdc.201402557

Reference yield:

4-Bromo-3-methylbenzoic acid methyl ester (148547-19-7) → tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate (1141475-62-8)

Guidance literature:

Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere

2: 96 h / Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

4: sodium hydroxide / ethanol / 1 h / 60 °C

5: coupling reagent / 0 - 20 °C / Inert atmosphere

6: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); potassium carbonate; sodium hydroxide; In ethanol; chloroform; water; toluene; acetonitrile;

DOI:10.1002/cmdc.201402557

upstream raw materials:

3-(bromomethyl)-4-fluorobenzonitrile

4-Bromo-3-methylbenzoic acid methyl ester

methyl 4-bromo-3-(bromomethyl)benzoate

methyl 4-bromo-3-(methoxymethyl)benzoate

Downstream raw materials:

N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride