N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

Base Information

Chemical Name:N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride
CAS No.:1141473-18-8
Molecular Formula:C₂₇H₂₆FN₃O₄*ClH
Molecular Weight:511.98
Hs Code.:

Synonyms:N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

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Chemical Property of N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

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Technology Process of N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

There total 10 articles about N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1141475-62-8
tert-butyl N-(2-fluoro-5-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate

: 1141473-18-8
N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201402557

Reference yield:

: 856935-35-8
3-(bromomethyl)-4-fluorobenzonitrile

: 1141473-18-8
N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 15 h / 20 °C

2: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

3: coupling reagent / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

5: sodium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: C₁₅H₁₉FN₂O₂

: 1141473-18-8
N-(2-fluoro-5-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

2: coupling reagent / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

4: sodium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C

With hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557