2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

Base Information

Chemical Name:2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide
CAS No.:1089187-43-8
Molecular Formula:C₂₇H₃₆F₃N₃O₅S
Molecular Weight:571.661
Hs Code.:

Synonyms:2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

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Chemical Property of 2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

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Technology Process of 2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

There total 4 articles about 2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.6%

: 10147-37-2
Isopropylsulfonyl chloride

: 1089187-35-8
2,2-dimethyl-5-amino-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-2,3-dihydro-benzofuran

: 1089187-43-8
2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 1089187-68-7
2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

: 1089187-43-8
2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

2: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane;

Reference yield:

: 113194-07-3
2,2-dimethyl-5-nitro-2,3-dihydro-benzofuran-7-ol

: 1089187-43-8
2-propyl-sulfonyl-N-(2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazino]-ethoxy}-benzofuran-5-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / Heating / reflux

2: sodium hydroxide / water / 8.5 h / Heating / reflux

3: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

4: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;