2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

Base Information

Chemical Name:2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran
CAS No.:1089187-68-7
Molecular Formula:C₂₄H₂₈F₃N₃O₅
Molecular Weight:495.499
Hs Code.:

Synonyms:2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

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Chemical Property of 2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

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Technology Process of 2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

There total 2 articles about 2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.3%

: 1034706-53-0
1-[2-methoxy-5-(trifluoromethyl)phenyl]piperazine hydrochloride

: 1089187-62-1
2,2-dimethyl-5-nitro-7-(2-chloro-ethoxy)-2,3-dihydro-benzofuran

: 1089187-68-7
2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

Guidance literature:: With sodium hydroxide; In water; for 8.5h; Heating / reflux;

Reference yield:

: 113194-07-3
2,2-dimethyl-5-nitro-2,3-dihydro-benzofuran-7-ol

: 1089187-68-7
2,2-dimethyl-5-nitro-7-{2-[4-(2-methoxy-5-trifluoro-methyl-phenyl)-piperazine-1-yl]-ethoxy}-2,3-dihydro-benzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / Heating / reflux

2: sodium hydroxide / water / 8.5 h / Heating / reflux

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In water;