(S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

Base Information

Chemical Name:(S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile
CAS No.:1208117-63-8
Molecular Formula:C₂₄H₃₀N₂O₂Si
Molecular Weight:406.6
Hs Code.:

Synonyms:(S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

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Chemical Property of (S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

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Technology Process of (S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

There total 2 articles about (S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1042150-58-2
N-benzyl-N-{2-[3-(tert-butyldimethylsilyloxy)prop-1-en-2-yl]phenyl}-1-cyanoformamide

: 1208117-63-8
(S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-5,5’,6,6’,7,7’,8,8’-octahydro-1,1-binaphthylphosphinite diisopropylamidite; In tetrahydrofuran; at 100 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Sealed vial; Inert atmosphere;
DOI:10.1016/j.tet.2010.02.096

Reference yield:

: 1042150-58-2
N-benzyl-N-{2-[3-(tert-butyldimethylsilyloxy)prop-1-en-2-yl]phenyl}-1-cyanoformamide

: C₂₄H₃₀N₂O₂Si

: 1208117-63-8
(S)-2-(1-benzyl-3-((tert-butyldimethylsilyloxy)methyl)-2-oxo-indolin-3-yl)acetonitrile

Guidance literature:: With C₂₈H₂₆NO₂P; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; decalin; at 100 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.01.073