5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

Base Information

Chemical Name:5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene
CAS No.:252336-78-0
Molecular Formula:C₁₈H₂₆FN₃O₄
Molecular Weight:367.421
Hs Code.:

Synonyms:5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

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Chemical Property of 5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

Chemical Property:

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Technology Process of 5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

There total 4 articles about 5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252336-77-9
5-Amino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

: 541-41-3
chloroformic acid ethyl ester

: 252336-78-0
5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

Guidance literature:: In pyridine; ice-water;

Reference yield:

: 3(R)-(t-butoxycarbonyl)-aminopyrrolidine

: 252336-78-0
5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

3.1: pyridine / 0.5 h / 0 °C

3.2: 1 h / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In pyridine; ethyl acetate; acetonitrile;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 252336-78-0
5-Ethoxycarbonylamino-2-((3R)-3-(t-butoxycarbonyl)aminopyrrolidin-1-yl)fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

3.1: pyridine / 0.5 h / 0 °C

3.2: 1 h / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In pyridine; ethyl acetate; acetonitrile;