4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride

Base Information

• Chemical Name: 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride
• CAS No.: 1610893-02-1
• Molecular Formula: C₁₂H₁₉N₅O₃S
• Molecular Weight: 313.381
• Mol file: 1610893-02-1.mol

Synonyms:4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride

Chemical Property of 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride

There total 5 articles about 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N′-di-Boc-guanidino-N″-(4-sulfamoyl-benzyl)-butyramide (1610893-00-9) → 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride (1610893-02-1)

Guidance literature:

With hydrogenchloride; at 20 ℃;

DOI:10.1016/j.bmcl.2014.06.024

Reference yield:

tert-butyl (4-oxo-4((4-sulfamoylbenzyl)amino)butyl)carbamate → 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride (1610893-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 20 °C

2: triethylamine / chloroform / 20 °C

3: hydrogenchloride / 20 °C

With hydrogenchloride; triethylamine; In chloroform;

DOI:10.1016/j.bmcl.2014.06.024

Reference yield:

4-homosulfanilamide (138-39-6) → 4-guanidino-N-(4-sulfamoyl-benzyl)-butyramide hydrochloride (1610893-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 65 h / 0 - 20 °C

2: hydrogenchloride / 20 °C

3: triethylamine / chloroform / 20 °C

4: hydrogenchloride / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform;

DOI:10.1016/j.bmcl.2014.06.024

upstream raw materials:

4-homosulfanilamide

4-oxo-4-((4-sulfamoylbenzyl)amino)butan-1-aminium chloride

N,N′-di-Boc-guanidino-N″-(4-sulfamoyl-benzyl)-butyramide

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine