4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane

Base Information

• Chemical Name: 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane
• CAS No.: 353246-03-4
• Molecular Formula: C₂₂H₂₉N₅O₁₀S₂
• Molecular Weight: 587.632

Synonyms:4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane

Chemical Property of 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane

Chemical Property:

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Technology Process of 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane

There total 2 articles about 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-nitro-[N-(2{2[(2-nitrophenyl)sulfonylamino]ethylamino})ethyl]benzenesulfonamide (290325-99-4) → 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane (353246-03-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4020(01)00328-3

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane (353246-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / NaHCO₃ / tetrahydrofuran / 12 h / 20 °C

2: 82 percent / Et₃N / tetrahydrofuran / Heating

With sodium hydrogencarbonate; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)00328-3

Reference yield: 93.0%

C29H29NO3S (941688-82-0) + 4-((tert-butoxycarbonyl)methyl)-1,7-bis(2-nitrophenylsulfonyl)-1,4,7-triazaheptane (353246-03-4) → C51H54N6O11S3 (941688-85-3)

Guidance literature:

With tributylphosphine; di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2007.03.024

upstream raw materials:

bromoacetic acid tert-butyl ester

2-nitro-[N-(2{2[(2-nitrophenyl)sulfonylamino]ethylamino})ethyl]benzenesulfonamide

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-acetate

C₃₀H₃₆N₆O₁₁S₂

C₃₂H₃₈N₆O₁₁S₂

C₅₁H₅₄N₆O₁₁S₃

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