C₃₉H₄₄FN₅O₆S*ClH

Base Information

Chemical Name:C₃₉H₄₄FN₅O₆S*ClH
CAS No.:1565779-32-9
Molecular Formula:C₃₉H₄₄FN₅O₆S*ClH
Molecular Weight:766.334
Hs Code.:

C<sub>39</sub>H<sub>44</sub>FN<sub>5</sub>O<sub>6</sub>S*ClH

Synonyms:C₃₉H₄₄FN₅O₆S*ClH

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Chemical Property of C₃₉H₄₄FN₅O₆S*ClH

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Technology Process of C₃₉H₄₄FN₅O₆S*ClH

There total 20 articles about C₃₉H₄₄FN₅O₆S*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1565770-99-1
tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

: 1565779-32-9
C₃₉H₄₄FN₅O₆S*ClH

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: 847547-91-5
2-chloro-3-hydroxyquinoline-4-carboxylic acid

: 1565779-32-9
C₃₉H₄₄FN₅O₆S*ClH

Guidance literature:: Multi-step reaction with 19 steps

1.1: methanol; toluene / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

5.1: tetrahydrofuran / 0 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

7.1: boron tribromide / dichloromethane / 1 h / 20 °C

8.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

9.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

10.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

10.2: 36 h / 20 °C

11.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

12.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

13.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

14.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

15.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

16.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; p-benzoquinone / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

17.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

18.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Reflux

18.2: 58 h / 20 - 50 °C

19.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; palladium 10% on activated carbon; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; hydrogen; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1565779-32-9
C₃₉H₄₄FN₅O₆S*ClH

Guidance literature:: Multi-step reaction with 18 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

4.1: tetrahydrofuran / 0 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

6.1: boron tribromide / dichloromethane / 1 h / 20 °C

7.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

8.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

9.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

9.2: 36 h / 20 °C

10.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

11.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

12.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

13.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

14.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

15.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; p-benzoquinone / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

16.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

17.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Reflux

17.2: 58 h / 20 - 50 °C

18.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; palladium 10% on activated carbon; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; hydrogen; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;