3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide
CAS No.:1401937-60-7
Molecular Formula:C₂₈H₃₄BrNO₃
Molecular Weight:512.487
Hs Code.:

Synonyms:3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

There total 4 articles about 3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1401937-96-9
3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethoxy)estra-1(10),2,4-trien-16-yl]methyl}benzamide

: 1401937-60-7
3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 2.33333h;

Reference yield:

: 1014704-30-3
3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

: 1401937-60-7
3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / acetone / 5 h / 60 °C

2.1: sodium periodate / ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 0.03 h / 0 °C

2.2: 0.33 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane; tetrahydrofuran / 2.33 h / 0 °C

With sodium periodate; carbon tetrabromide; triphenylphosphine; sodium hydroxide; ruthenium(III) trichloride hydrate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; acetonitrile;

Reference yield:

: 1401937-95-8
3-{[(16β,17β)-17-hydroxy-3-(prop-2-en-1-yloxy)estra-1(10),2,4-trien-16-yl]methyl}benzamide

: 1401937-60-7
3-{[(16β,17β)-3-(2-bromoethoxy)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium periodate / ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 0.03 h / 0 °C

1.2: 0.33 h / 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane; tetrahydrofuran / 2.33 h / 0 °C

With sodium periodate; carbon tetrabromide; triphenylphosphine; ruthenium(III) trichloride hydrate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;