3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide
CAS No.:1014704-30-3
Molecular Formula:C₂₆H₃₁NO₃
Molecular Weight:405.537
Hs Code.:

Synonyms:3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

There total 3 articles about 3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3-(3,17β-dihydroxy-estra-1,3,5(10)-trien-16-ylidenemethyl)-benzamide

: 1014704-30-3
3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2007.11.007

Reference yield:

: 1408168-73-9
potassium [2-(benzyloxy)ethyl]-trifluoroboranuide

: 126534-87-0
3-carboxamidobenzaldehyde

: 92817-04-4
estrone triflate

: 1014704-30-3
3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

: 1318265-17-6
3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethyl)estra-1,3,5(10)-trien-16-yl]methyl}benzamide

Guidance literature:: potassium [2-(benzyloxy)ethyl]-trifluoroboranuide; estrone triflate; With caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; water; at 90 ℃; for 24h; Inert atmosphere;

3-carboxamidobenzaldehyde; With sodium hydroxide; In ethanol; dichloromethane; water; at 20 ℃; for 5h; stereoselective reaction; Further stages;
DOI:10.1021/acs.oprd.8b00402

Reference yield:

: 53-16-7
Estrone

: 1014704-30-3
3-{[(16β,17β)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: palladium dichloride; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 24 h / 90 °C / Inert atmosphere

2.2: 5 h / 20 °C

With caesium carbonate; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; dichloromethane; water; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.oprd.8b00402