2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione

Base Information

• Chemical Name: 2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione
• CAS No.: 1354344-56-1
• Molecular Formula: C₁₉H₁₅BrCl₂N₂O₃
• Molecular Weight: 472.139

Synonyms:2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione

Chemical Property of 2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione

Chemical Property:

Purity/Quality:

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Technology Process of 2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione

There total 2 articles about 2-[⁽¹⁴⁾C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-[(14)C]-(R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione (1354344-60-7) + acetyl chloride (75-36-5) → 2-[(14)C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione (1354344-56-1)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -25 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/jlcr.1920

Reference yield:

(R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide dihydrochloride → 2-[(14)C]-(R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione (1354344-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; toluene / 10 h / 0 - 20 °C

2: potassium hexamethylsilazane / tetrahydrofuran; toluene / 12 h / -25 - 20 °C / Inert atmosphere

With potassium hexamethylsilazane; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1002/jlcr.1920

upstream raw materials:

2-[⁽¹⁴⁾C]-(R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione

acetyl chloride

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