[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester
CAS No.:817208-84-7
Molecular Formula:C₂₅H₂₈ClN₅O₄
Molecular Weight:497.981
Hs Code.:

Synonyms:[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

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Chemical Property of [4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

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Technology Process of [4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

There total 4 articles about [4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 405939-70-0
5-{5-[(tert-butoxycarbonyl)(3-chlorophenyl)amino]pyrimidin-4-yl}nicotinic acid

: 75-65-0
tert-butyl alcohol

: 817208-84-7
[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In toluene; at 70 - 100 ℃; for 4.5h;
DOI:10.1021/jm040099a

Reference yield:

: 405939-98-2
5-(5-bromopyrimidin-4-yl)nicotinic acid ethyl ester

: 817208-84-7
[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / Pd₂(dba)3; DPPF; Cs₂CO₃ / dioxane / 46 h / 110 °C

2: DMAP / CH₂Cl₂ / 4 h / 20 °C

3: aq. NaOH / methanol / 18 h / 20 °C

4: 81 percent / diphenylphosphoryl azide; Et₃N / toluene / 4.5 h / 70 - 100 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; sodium hydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; diphenylphosphoranyl azide; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; toluene; 4: Curtius rearrangement;
DOI:10.1021/jm040099a

Reference yield:

: 405939-99-3
5-[5-(3-chlorophenylamino)pyrimidin-4-yl]nicotinic acid ethyl ester

: 817208-84-7
[4-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrimidin-5-yl](3-chlorophenyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / CH₂Cl₂ / 4 h / 20 °C

2: aq. NaOH / methanol / 18 h / 20 °C

3: 81 percent / diphenylphosphoryl azide; Et₃N / toluene / 4.5 h / 70 - 100 °C

With dmap; sodium hydroxide; diphenylphosphoranyl azide; triethylamine; In methanol; dichloromethane; toluene; 3: Curtius rearrangement;
DOI:10.1021/jm040099a