7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

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Chemical Name:7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate
CAS No.:1053239-67-0
Molecular Formula:C₄H₄O₄*C₂₂H₂₈ClN₃O₃S₂
Molecular Weight:598.141
Hs Code.:

Synonyms:7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

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Chemical Property of 7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

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Technology Process of 7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

There total 15 articles about 7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928628-29-9
7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 7-[(1S)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

: 1053239-67-0
7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

Guidance literature:: In methanol; at 20 ℃; for 2h;

Reference yield:

: 22568-07-6
1-chloro-2-[(E)-2-nitrovinyl]benzene

: 7-[(1S)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

: 1053239-67-0
7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 0.58 h / 0 - 10 °C / Heating / reflux

1.2: 0.5 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 3.17 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1.75 h / 35 - 50 °C

3.2: 2 h / 20 - 25 °C

4.1: 2,2'-azobis(isobutyronitrile) / 1.25 h / 65 °C

5.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 0.67 h / 25 °C

6.1: methanol; acetic acid / 1 h / 20 °C

6.2: 2 h

7.1: formic acid; water / 18 h / 20 °C

8.1: methanol / 2 h / 20 °C

With lithium aluminium tetrahydride; formic acid; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; sulfur trioxide pyridine complex; sodium hydride; triethylamine; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 7-[(1S)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

: 1053239-67-0
7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}-amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one monofumarate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 3.17 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1.75 h / 35 - 50 °C

2.2: 2 h / 20 - 25 °C

3.1: 2,2'-azobis(isobutyronitrile) / 1.25 h / 65 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 0.67 h / 25 °C

5.1: methanol; acetic acid / 1 h / 20 °C

5.2: 2 h

6.1: formic acid; water / 18 h / 20 °C

7.1: methanol / 2 h / 20 °C

With formic acid; 2,2'-azobis(isobutyronitrile); water; sulfur trioxide pyridine complex; sodium hydride; triethylamine; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;