Technology Process of C19H28N2O
There total 5 articles about C19H28N2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R,7aS)-3-Isopropyl-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-1-one;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
Inert atmosphere;
1-bromo-butane;
In
tetrahydrofuran; hexane;
at -78 - 23 ℃;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol403320d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium sulfate; acetic acid / toluene / 110 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere
2.2: -78 - 23 °C / Inert atmosphere
With
magnesium sulfate; acetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol403320d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isobutyl chloroformate; triethylamine / dichloromethane / 0.33 h / 0 °C
1.2: 0 - 23 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 23 °C
3.1: magnesium sulfate; acetic acid / toluene / 110 °C
4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere
4.2: -78 - 23 °C / Inert atmosphere
With
magnesium sulfate; acetic acid; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; isobutyl chloroformate;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol403320d
