benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Base Information

Chemical Name:benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
CAS No.:1208332-45-9
Molecular Formula:C₁₀H₁₆O₄S*C₁₉H₂₉N₃O₂
Molecular Weight:563.759
Hs Code.:

Synonyms:benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

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Chemical Property of benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

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Technology Process of benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

There total 9 articles about benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: cis-benzyl-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1208332-45-9
benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Guidance literature:: With water; In Isopropyl acetate; toluene; at 75 ℃; for 3h; Product distribution / selectivity;

Reference yield: 14.0%

: benzyl (1SR,3RS)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1208332-45-9
benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Guidance literature:: In Isopropyl acetate; water; toluene; at 75 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 930-68-7
cyclohexenone

: 1208332-45-9
benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 20 °C

2.1: potassium carbonate; hydroxylamine hydrochloride / ethanol / 16.5 h / 0 - 20 °C

3.1: hydrogen; ammonia / Raney nickel / toluene; ethanol / 0.5 h / 3750.38 Torr

3.2: 50 °C

4.1: potassium carbonate / toluene; water / 16 h / 0 - 20 °C

5.1: toluene; water; Isopropyl acetate / 3 h / 75 °C

With hydroxylamine hydrochloride; ammonia; hydrogen; potassium carbonate; Raney nickel; In ethanol; Isopropyl acetate; water; toluene;