benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

Base Information

Chemical Name:benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate
CAS No.:1390662-42-6
Molecular Formula:C₂₀H₁₄BrClF₂N₂O₃
Molecular Weight:483.697
Hs Code.:

Synonyms:benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

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Chemical Property of benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

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Technology Process of benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

There total 4 articles about benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1390662-60-8
benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-picolinate

: 1390662-42-6
benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

Guidance literature:: With N-Bromosuccinimide; In 1,2-dichloro-ethane; at 23 ℃; for 72h;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1390662-42-6
benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 5 steps

1: 4 h / 100 °C / Inert atmosphere

2: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 1.5 h / Reflux; Inert atmosphere

3: cesium fluoride / dimethyl sulfoxide / 6 h / 105 °C / Inert atmosphere

4: ammonia / dimethyl sulfoxide / 0.5 h

5: N-Bromosuccinimide / 1,2-dichloro-ethane / 72 h / 23 °C

With N-Bromosuccinimide; ammonia; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1390662-56-2
benzyl 4,5,6-trichloropicolinate

: 1390662-42-6
benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 1.5 h / Reflux; Inert atmosphere

2: cesium fluoride / dimethyl sulfoxide / 6 h / 105 °C / Inert atmosphere

3: ammonia / dimethyl sulfoxide / 0.5 h

4: N-Bromosuccinimide / 1,2-dichloro-ethane / 72 h / 23 °C

With N-Bromosuccinimide; ammonia; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;