(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

Base Information

Chemical Name:(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate
CAS No.:1390662-62-0
Molecular Formula:C₂₅H₂₅ClF₂N₂O₃Si
Molecular Weight:503.02
Hs Code.:

Synonyms:(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

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Chemical Property of (E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

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Technology Process of (E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

There total 8 articles about (E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390662-42-6
benzyl 4-amino-3-bromo-6-(4-chloro-2-fluoro-3-methoxy-phenyl)-5-fluoropicolinate

: 58207-97-9
tributyl[(E)-2-trimethylsilylethenyl]stannane

: 1390662-62-0
(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 23 - 90 ℃; for 20h;

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 1390662-62-0
(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile) / 20 h / 80 - 110 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 h / 23 - 90 °C

With 2,2'-azobis(isobutyronitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 1390662-60-8
benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-picolinate

: 1390662-62-0
(E)-benzyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(2-(trimethylsilyl)vinyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 72 h / 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 h / 23 - 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;