13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate

Base Information

• Chemical Name: 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate
• CAS No.: 1393714-23-2
• Molecular Formula: C₂₅H₂₅N₃O₃
• Molecular Weight: 415.492
• Mol file: 1393714-23-2.mol

Synonyms:13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate

Chemical Property of 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate

There total 7 articles about 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6,8,13,13a-tetrahydro-13-methyl-5H-isoquinolino[1,2-b]quinazolin-10-ol (1393714-15-2) + 3-methoxyphenyl isocyanate (18908-07-1) → 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate (1393714-23-2)

Guidance literature:

6,8,13,13a-tetrahydro-13-methyl-5H-isoquinolino[1,2-b]quinazolin-10-ol; With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

3-methoxyphenyl isocyanate; In dichloromethane; at 20 ℃;

DOI:10.1021/ml3001825

Reference yield:

10-hydroxy-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one (1393714-33-4) → 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate (1393714-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.25 h / 20 °C

2.2: 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ml3001825

Reference yield:

3,4-dihydroisoquinoline (3230-65-7) → 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate (1393714-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 24 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.25 h / 20 °C

3.2: 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ml3001825

upstream raw materials:

6-hydroxy-1-methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

10-hydroxy-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

3,4-dihydroisoquinoline

6,8,13,13a-tetrahydro-13-methyl-5H-isoquinolino[1,2-b]quinazolin-10-ol