(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

Base Information

Chemical Name:(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one
CAS No.:186960-90-7
Molecular Formula:C₁₇H₂₂O₃
Molecular Weight:274.36
Hs Code.:

Synonyms:(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

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Chemical Property of (3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

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Technology Process of (3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

There total 6 articles about (3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 186960-89-4
(3aR,4S,7R,7aR)-3a,4,5,6,7,7a-hexahydro-4-benzyloxymethylindano(1,7-cd)isoxazole

: 186960-90-7
(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

Guidance literature:: With Trimethyl borate; Raney Ni(W₂); In methanol; water; for 12h; Ambient temperature;
DOI:10.3987/COM-96-7655

Reference yield:

: 178945-61-4
(1'S,6'S)-2-(6'-benzyloxymethyl-2'-cyclohexenyl)ethanol

: 186960-90-7
(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / tetrapropylammonium perruthenate, 4-methylmorpholin N-oxide, 4A-molecular sieves / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 71 percent / KF, tetrabutylammonium chloride / toluene / 3 h / Ambient temperature

3: pyridine / 0.5 h / Ambient temperature

4: NaBH₄ / ethanol / 0.5 h / 0 °C

5: 99 percent / p-chlorophenyl isocyanate, Et₃N / toluene / 6 h / 60 °C / in sealed tube

6: 45 percent / trimethoxyborane / Raney Ni(W₂) / methanol; H₂O / 12 h / Ambient temperature

With potassium fluoride; sodium tetrahydroborate; tetrapropylammonium perruthennate; Trimethyl borate; 4 A molecular sieve; tetrabutyl-ammonium chloride; p-chlorphenylisocyanate; 4-methylmorpholine N-oxide; triethylamine; Raney Ni(W₂); In pyridine; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.3987/COM-96-7655

Reference yield:

: 186960-86-1
(1'S,6'S)-(6'-benzyloxymethyl-2'-cyclohexenyl)acetaldehyde

: 186960-90-7
(3aR,4S,7aR)-4-benzyloxymethyl-7-hydroxy-3a,4,5,6,7,7a-hexahydroindan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / KF, tetrabutylammonium chloride / toluene / 3 h / Ambient temperature

2: pyridine / 0.5 h / Ambient temperature

3: NaBH₄ / ethanol / 0.5 h / 0 °C

4: 99 percent / p-chlorophenyl isocyanate, Et₃N / toluene / 6 h / 60 °C / in sealed tube

5: 45 percent / trimethoxyborane / Raney Ni(W₂) / methanol; H₂O / 12 h / Ambient temperature

With potassium fluoride; sodium tetrahydroborate; Trimethyl borate; tetrabutyl-ammonium chloride; p-chlorphenylisocyanate; triethylamine; Raney Ni(W₂); In pyridine; methanol; ethanol; water; toluene;
DOI:10.3987/COM-96-7655