4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

Base Information

Chemical Name:4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol
CAS No.:153765-12-9
Molecular Formula:C₃₃H₃₅N₃O₈
Molecular Weight:601.656
Hs Code.:

Synonyms:4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

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Chemical Property of 4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

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Technology Process of 4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

There total 3 articles about 4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 3544-99-8
thymidine-5'-carboxylic acid

: 153765-10-7
2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethanamine

: 153765-12-9
4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73706-3

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 153765-12-9
4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 85.9 percent / pyridine / 2 h / Ambient temperature

2: 64.5 percent / piperidine / CH₂Cl₂ / 1 h / Ambient temperature

3: 86.2 percent / 1-hydroxybenzotriazole monohydrate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 1.) 0-5 deg C -> room temperature, 3 h, 2.) room temperature, 15 h

With piperidine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013239

Reference yield:

: 153765-09-4
9-fluorenylmethoxycarbonyl-O-(4,4'-dimethoxytrityl)ethanolamine

: 153765-12-9
4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 64.5 percent / piperidine / CH₂Cl₂ / 1 h / Ambient temperature

2: 86.2 percent / 1-hydroxybenzotriazole monohydrate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 1.) 0-5 deg C -> room temperature, 3 h, 2.) room temperature, 15 h

With piperidine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013239