3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride

Base Information

• Chemical Name: 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride
• CAS No.: 100287-51-2
• Molecular Formula: C₂₆H₃₂N₄O₄*ClH
• Molecular Weight: 501.025
• Mol file: 100287-51-2.mol

Synonyms:3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride

Chemical Property of 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride

There total 4 articles about 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.3%

5-amino-3-cyclopentyl-1-methylpyrazole (92406-39-8) + 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid cyclohexyl ester (61312-62-7) → 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride (100287-51-2)

Guidance literature:

In tert-butyl alcohol; at 80 ℃; for 24h;

DOI:10.1248/cpb.35.3235

Reference yield:

3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride (100287-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74.4 percent / ethanol / 5 h / Heating

2: 64.3 percent / 2-methyl-propan-2-ol / 24 h / 80 °C

In ethanol; tert-butyl alcohol;

DOI:10.1248/cpb.35.3235

Reference yield:

cyclohexyl 3-oxobutanoate (6947-02-0) → 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid cyclohexyl ester; hydrochloride (100287-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97.3 percent / AcOH, piperidine / benzene / 24 h / 30 - 45 °C

2: 64.3 percent / 2-methyl-propan-2-ol / 24 h / 80 °C

With piperidine; acetic acid; In tert-butyl alcohol; benzene;

DOI:10.1248/cpb.35.3235

upstream raw materials:

5-amino-3-cyclopentyl-1-methylpyrazole

2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid cyclohexyl ester

cyclohexyl 3-oxobutanoate

3-cyclopentyl-3-oxopropanenitrile

Refernces