Technology Process of 1-bromo-3-(2-methoxypropan-2-yl)-5-(1-methylcyclopropyl)benzene
There total 6 articles about 1-bromo-3-(2-methoxypropan-2-yl)-5-(1-methylcyclopropyl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-bromo-5-(1-methylcyclopropyl)phenyl)propan-2-ol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 1h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 70 ℃;
sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -40 °C
1.2: 1 h / -40 - 20 °C
2.1: palladium diacetate / diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere
4.2: 70 °C / sealed tube
With
n-butyllithium; sodium hydride;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; hexane; mineral oil;
1.2: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate / diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere
3.2: 70 °C / sealed tube
With
n-butyllithium; sodium hydride;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; hexane; mineral oil;