benzyl-(1-phenethyl-piperidin-4-yl)-amine

Base Information

• Chemical Name: benzyl-(1-phenethyl-piperidin-4-yl)-amine
• CAS No.: 733674-39-0
• Molecular Formula: C₂₀H₂₆N₂
• Molecular Weight: 294.44
• Mol file: 733674-39-0.mol

Synonyms:benzyl-(1-phenethyl-piperidin-4-yl)-amine

Chemical Property of benzyl-(1-phenethyl-piperidin-4-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl-(1-phenethyl-piperidin-4-yl)-amine

There total 8 articles about benzyl-(1-phenethyl-piperidin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl-(1-phenethyl-piperidin-4-ylidene)-amine → benzyl-(1-phenethyl-piperidin-4-yl)-amine (733674-39-0)

Guidance literature:

With thiophene; hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00139a003

Reference yield:

8-Phenethyl-1,4-dioxa-8-aza-spiro[4.5]decane; hydrochloride (24089-69-8) → benzyl-(1-phenethyl-piperidin-4-yl)-amine (733674-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 2 N HCl in acetic acid / Heating

2: H₂ / 10 percent Pd/C / methanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00150a029

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → benzyl-(1-phenethyl-piperidin-4-yl)-amine (733674-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: thiophene, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

With thiophene; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00139a003

upstream raw materials:

1-(2-phenylethyl)-4-piperidinone

benzylamine

N-(1-phenethylpiperidin-4-yl)benzamide

benzoyl chloride

Downstream raw materials:

(2-Nitro-phenyl)-(1-phenethyl-piperidin-4-yl)-amine

Benzyl-(1-benzyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine

Benzyl-(1-ethyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine

3-(2-Amino-phenyl)-1-benzyl-1-(1-phenethyl-piperidin-4-yl)-thiourea

Refernces

• 1、 Janssens,Torremans,Janssen,Stokbroekx,Luyckx. "New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines". . p. 1925 - 1933. Retrieved 2007/10/02.