C₅₂H₆₈F₂N₄O₈

Base Information

• Chemical Name: C₅₂H₆₈F₂N₄O₈
• CAS No.: 1613643-93-8
• Molecular Formula: C₅₂H₆₈F₂N₄O₈
• Molecular Weight: 915.131
• Mol file: 1613643-93-8.mol

Synonyms:C₅₂H₆₈F₂N₄O₈

Chemical Property of C₅₂H₆₈F₂N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₆₈F₂N₄O₈

There total 7 articles about C₅₂H₆₈F₂N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H43BN2O6 (1613643-91-6) + C12H6Br2F2 (1613643-92-7) → C52H68F2N4O8 (1613643-93-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 20 - 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

3,5-dimethylphenyl iodide (22445-41-6) → C52H68F2N4O8 (1613643-93-8)

Guidance literature:

Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 8 h / Reflux

2: acetonitrile; water / 0.75 h / 20 - 64 °C

3: borane-THF / tetrahydrofuran / 0 °C / Reflux

4: triethylamine / tetrahydrofuran / 20 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 20 - 80 °C / Inert atmosphere

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; 2,2'-azobis(isobutyronitrile); potassium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

1,3-biscyanomethyl-5-iodobenzene → C52H68F2N4O8 (1613643-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 °C / Reflux

2: triethylamine / tetrahydrofuran / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 20 - 80 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 20 - 100 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; potassium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

upstream raw materials:

3,5-dimethylphenyl iodide

1,3-bis(bromomethyl)-5-iodobenzene

C₂₀H₃₁IN₂O₄

C₁₀H₁₅IN₂

Downstream raw materials:

C₃₂H₃₆F₂N₄