N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Base Information

Chemical Name:N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide
CAS No.:1201663-64-0
Molecular Formula:C₂₉H₂₄Cl₂F₂N₂O
Molecular Weight:525.425
Hs Code.:

Synonyms:N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Suppliers and Price of N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

There total 5 articles about N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1201663-63-9
3-(aminomethyl)-N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)benzamide

: 459-57-4
4-fluorobenzaldehyde

: 1201663-64-0
N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Guidance literature:: 3-(aminomethyl)-N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)benzamide; 4-fluorobenzaldehyde; In dichloromethane; isopropyl alcohol; at 20 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; isopropyl alcohol; at 20 ℃; for 20h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; isopropyl alcohol; for 0.333333h;

Reference yield:

: 10203-08-4
3,5-dichlorobenzaldehyde

: 1201663-64-0
N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; isopropyl alcohol / 1 h / 20 °C

1.2: 22 h / 20 °C / Inert atmosphere

1.3: 0.2 h

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4.1: dichloromethane; isopropyl alcohol / 1.5 h / 20 °C

4.2: 20 h / 20 °C / Inert atmosphere

4.3: 0.33 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1179959-12-6
N-(3,5-dichlorobenzyl)-1-(4-fluorophenyl)methanamine

: 1201663-64-0
N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: dichloromethane; isopropyl alcohol / 1.5 h / 20 °C

3.2: 20 h / 20 °C / Inert atmosphere

3.3: 0.33 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;