tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate
CAS No.:1201663-62-8
Molecular Formula:C₂₇H₂₇Cl₂FN₂O₃
Molecular Weight:517.427
Hs Code.:

Synonyms:tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

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Chemical Property of tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

Chemical Property:

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Technology Process of tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

There total 3 articles about tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1179959-12-6
N-(3,5-dichlorobenzyl)-1-(4-fluorophenyl)methanamine

: 117445-22-4
3-(tert-butoxycarbonylamino-methyl)benzoic acid

: 1201663-62-8
tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 10203-08-4
3,5-dichlorobenzaldehyde

: 1201663-62-8
tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; isopropyl alcohol / 1 h / 20 °C

1.2: 22 h / 20 °C / Inert atmosphere

1.3: 0.2 h

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 140-75-0
para-fluorobenzylamine

: 1201663-62-8
tert-butyl 3-((3,5-dichlorobenzyl)(4-fluorobenzyl)carbamoyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; isopropyl alcohol / 1 h / 20 °C

1.2: 22 h / 20 °C / Inert atmosphere

1.3: 0.2 h

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;