racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Base Information

Chemical Name:racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine
CAS No.:514805-98-2
Molecular Formula:C₂₇H₂₈FNO₂
Molecular Weight:417.523
Hs Code.:

Synonyms:racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

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Chemical Property of racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

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Technology Process of racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

There total 6 articles about racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol

: 514805-98-2
racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.416667h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 514805-98-2
racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 24 h / Heating

2.1: 2.87 g / NaBH₄ / methanol / 0 - 20 °C

3.1: 46 percent / p-TsOH / toluene / 3 h / Heating

4.1: NaBH₄; BF₃*Et₂O / tetrahydrofuran / 2 h / 20 °C

4.2: 83 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran; ethanol / 55 °C

5.1: 48 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 5.1: Swern oxidation;
DOI:10.1021/jm020275k

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 514805-98-2
racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 24 h / Heating

2.1: 2.87 g / NaBH₄ / methanol / 0 - 20 °C

3.1: 46 percent / p-TsOH / toluene / 3 h / Heating

4.1: NaBH₄; BF₃*Et₂O / tetrahydrofuran / 2 h / 20 °C

4.2: 83 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran; ethanol / 55 °C

5.1: 48 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 5.1: Swern oxidation;
DOI:10.1021/jm020275k