3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride

Base Information

• Chemical Name: 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride
• CAS No.: 1447330-50-8
• Molecular Formula: C₂₃H₂₆N₄O₄*ClH
• Molecular Weight: 458.945
• Mol file: 1447330-50-8.mol

Synonyms:3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride

Chemical Property of 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride

There total 11 articles about 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid (1447332-14-0) → 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride (1447330-50-8)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 1h;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-(1-oxo-1,3-dihydroisoindol-2-yl)butyric acid (1335100-69-0) → 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride (1447330-50-8)

Guidance literature:

Multi-step reaction with 6 steps

1: nitric acid / water; sulfuric acid / 6 h / -5 °C

2: sulfuric acid / 3 h / Reflux

3: hydrogen; palladium on activated charcoal / methanol / 7 h / 20 °C

4: triethylamine / acetonitrile / -5 - 20 °C

5: sodium hydroxide / water; methanol / 20 °C

6: hydrogenchloride / dichloromethane / 1 h

With hydrogenchloride; sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; triethylamine; sodium hydroxide; In methanol; dichloromethane; sulfuric acid; water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-piperazine-4-yl-benzoic acid methyl ester (179003-08-8) → 3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride (1447330-50-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 20 °C

2: sodium hydroxide / water / 6 h / 40 °C

3: triethylamine / acetonitrile / -5 - 20 °C

4: sodium hydroxide / water; methanol / 20 °C

5: hydrogenchloride / dichloromethane / 1 h

With hydrogenchloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

upstream raw materials:

3-(1-oxo-1,3-dihydroisoindol-2-yl)butyric acid

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid

3-piperazine-4-yl-benzoic acid methyl ester