3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

Base Information

Chemical Name:3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid
CAS No.:1447332-14-0
Molecular Formula:C₂₈H₃₄N₄O₆
Molecular Weight:522.601
Hs Code.:

Synonyms:3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

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Chemical Property of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

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Technology Process of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

There total 10 articles about 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447331-70-5
3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester

: 1447332-14-0
3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2013.05.019

Reference yield:

: 1335100-69-0
3-(1-oxo-1,3-dihydroisoindol-2-yl)butyric acid

: 1447332-14-0
3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid / water; sulfuric acid / 6 h / -5 °C

2: sulfuric acid / 3 h / Reflux

3: hydrogen; palladium on activated charcoal / methanol / 7 h / 20 °C

4: triethylamine / acetonitrile / -5 - 20 °C

5: sodium hydroxide / water; methanol / 20 °C

With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; triethylamine; sodium hydroxide; In methanol; sulfuric acid; water; acetonitrile;
DOI:10.1016/j.bmc.2013.05.019

Reference yield:

: 179003-08-8
3-piperazine-4-yl-benzoic acid methyl ester

: 1447332-14-0
3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 20 °C

2: sodium hydroxide / water / 6 h / 40 °C

3: triethylamine / acetonitrile / -5 - 20 °C

4: sodium hydroxide / water; methanol / 20 °C

With triethylamine; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.1016/j.bmc.2013.05.019