N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

Base Information

Chemical Name:N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide
CAS No.:1609033-80-8
Molecular Formula:C₁₉H₁₆BrN₅O₃S₂
Molecular Weight:506.404
Hs Code.:

Synonyms:N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

Chemical Property:

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Technology Process of N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

There total 6 articles about N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429764-32-8
2-((4-(4-bromophenylsulfonamido)-1-methoxynaphthalen-2-yl)thio)acetamide

: 1609033-80-8
N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

Guidance literature:: With sodium azide; tetrachlorosilane; In acetonitrile; at 80 ℃; for 15h; Sealed tube;
DOI:10.1021/jm500010b

Reference yield:

: 1429765-70-7
2-iodo-1-methoxy-4-nitronaphthalene

: 1609033-80-8
N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; zinc(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 20 h / 60 °C / Inert atmosphere

2.1: iron; acetic acid / 1 h / 70 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

4.1: ammonium hydroxide / water / 1 h / 20 °C

5.1: sodium azide; tetrachlorosilane / acetonitrile / 15 h / 80 °C / Sealed tube

With pyridine; ammonium hydroxide; sodium azide; tetrachlorosilane; iron; caesium carbonate; acetic acid; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm500010b

Reference yield:

: 4900-63-4
1-methoxy-4-nitronaphthalene

: 1609033-80-8
N-(3-(((2H-tetrazol-5-yl)methyl)thio)-4-methoxynaphthalen-1-yl)-4-bromobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide; trifluoroacetic acid / Reflux; Inert atmosphere

2.1: caesium carbonate; zinc(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 h / 60 °C / Inert atmosphere

3.1: iron; acetic acid / 1 h / 70 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

5.1: ammonium hydroxide / water / 1 h / 20 °C

6.1: sodium azide; tetrachlorosilane / acetonitrile / 15 h / 80 °C / Sealed tube

With pyridine; ammonium hydroxide; N-iodo-succinimide; sodium azide; tetrachlorosilane; iron; caesium carbonate; acetic acid; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm500010b