N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

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Chemical Name:N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid
CAS No.:1000182-82-0
Molecular Formula:C₂HF₃O₂*C₂₆H₂₅FN₆O
Molecular Weight:570.546
Hs Code.:

Synonyms:N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

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Chemical Property of N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

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Technology Process of N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

There total 8 articles about N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000182-81-9
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

: 76-05-1
trifluoroacetic acid

: 1000182-82-0
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1000182-82-0
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: N-Bromosuccinimide / dichloromethane / 12 h

3.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

3.2: 2.5 h / 20 °C

3.3: 0.5 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

7.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

8.1: water; acetonitrile

With dmap; N-Bromosuccinimide; Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

: 1000183-46-9
3-bromo-5-fluoro-1-Boc-1H-indole

: 1000182-82-0
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

6.1: water; acetonitrile

With Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;