N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Base Information

Chemical Name:N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono
CAS No.:1000182-81-9
Molecular Formula:C₂₆H₂₅FN₆O
Molecular Weight:456.523
Hs Code.:

Synonyms:N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Suppliers and Price of N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

There total 7 articles about N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000183-49-2
4-(5-fluoro-1H-indol-3-yl)-N-(4-piperazin-1-ylphenyl)pyrimidin-2-amine

: 1759-53-1
cyclopropanecarboxylic acid

: 1000182-81-9
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1000182-81-9
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: N-Bromosuccinimide / dichloromethane / 12 h

3.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

3.2: 2.5 h / 20 °C

3.3: 0.5 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

7.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

With dmap; N-Bromosuccinimide; Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane;

Reference yield:

: 1000183-46-9
3-bromo-5-fluoro-1-Boc-1H-indole

: 1000182-81-9
N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono

Guidance literature:: Multi-step reaction with 5 steps

1.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

With Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane;