5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

Base Information

Chemical Name:5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide
CAS No.:859809-22-6
Molecular Formula:C₂₀H₂₅N₃O₃SSi
Molecular Weight:415.588
Hs Code.:

5-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

Synonyms:5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

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Chemical Property of 5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

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Technology Process of 5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

There total 3 articles about 5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 354812-10-5
2-[(aminocarbonyl)amino]-5-bromo-3-thiophenecarboxamide

: 163233-08-7
m-(tert-butyldimethylsiloxy)phenylacetylene

: 859809-22-6
5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

Guidance literature:: With copper(l) iodide; dichloropalladium bis(di-isopropylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; at 75 ℃;
DOI:10.1016/j.bmcl.2005.03.090

Reference yield:

: 10401-11-3
3-hydroxy phenylacetylene

: 859809-22-6
5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 20 °C

2: 70 percent / dichloropalladium bis(di-isopropylphosphino)ferrocene; CuI; i-Pr₂NEt / ethanol; N,N-dimethyl-acetamide / 75 °C

With 1H-imidazole; copper(l) iodide; dichloropalladium bis(di-isopropylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2005.03.090

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 859809-22-6
5-[3-(tert-butyl-dimethyl-silanyloxy)-phenylethynyl]-2-ureido-thiophene-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 20 °C

2: 70 percent / dichloropalladium bis(di-isopropylphosphino)ferrocene; CuI; i-Pr₂NEt / ethanol; N,N-dimethyl-acetamide / 75 °C

With 1H-imidazole; copper(l) iodide; dichloropalladium bis(di-isopropylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2005.03.090