<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Base Information

Chemical Name:<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane
CAS No.:145668-42-4
Molecular Formula:C₂₁H₄₀O₃Si
Molecular Weight:368.632
Hs Code.:

Synonyms:<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Suppliers and Price of <4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

There total 6 articles about <4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18173-64-3
tert-butyldimethylsilanol

: 145668-42-4
<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, r.t., 30 min, 2.) 55-60 deg C, 23 h

2: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

3: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

4: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

5: 91 percent / K₂CO₃ / methanol / 2.5 h

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00056a013

Reference yield:

: 145668-28-6
2-(tert-butyldimethylsilyloxy)methyl-3-chloroprop-1-ene

: 145668-42-4
<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 62 deg C, 1,5 h, 2.) THF, 62 deg C, 20 h

2: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -20 deg C, 45 min

3: 77 percent / Ph₃P, pyridine, diethyl azodicarboxylate / tetrahydrofuran / 5 h / -45 deg C to 0 deg C

4: 91 percent / K₂CO₃ / methanol / 2.5 h

With pyridine; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00056a013

Reference yield:

: 145668-31-1
-1-<2-(acetyloxy)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-methylene-1-butyl>-4-methylcyclohexene

: 145668-42-4
<4R(4α,4(R*),5β)>-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-2,2-dimethyl-4-<(4-methyl-1-cyclohexen-1-yl)methyl>1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / methanol / 2.5 h

With potassium carbonate; In methanol;
DOI:10.1021/jo00056a013