2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester

Base Information

• Chemical Name: 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester
• CAS No.: 247575-77-5
• Molecular Formula: C₅₁H₆₃N₃O₄
• Molecular Weight: 782.079

Synonyms:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester

Chemical Property of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester

Chemical Property:

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Technology Process of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester

There total 2 articles about 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(S)-2-(dibenzylamino)-4-methylpentanal (111060-65-2) + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester (247575-73-1) → 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S)-2-dibenzylamino-1-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-4-methyl-pentyl ester + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester (247575-77-5)

Guidance literature:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 6h;

(S)-2-(dibenzylamino)-4-methylpentanal; In diethyl ether; hexane; cyclohexane; at -78 - 20 ℃; for 12h;

DOI:10.1055/s-1999-3576

Reference yield: 44.0%

(2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1) + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-methyl-pentyl ester (143746-14-9) → 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S)-2-dibenzylamino-1-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-4-methyl-pentyl ester + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1R,2S)-2-dibenzylamino-1-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-4-methyl-pentyl ester + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester (247575-77-5)

Guidance literature:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-methyl-pentyl ester; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 6h;

(2S)-N,N-dibenzylphenylalaninal; In diethyl ether; hexane; cyclohexane; at -78 - 20 ℃; for 12h;

DOI:10.1055/s-1999-3576

Reference yield:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester (247575-77-5) → (2-Hydroxy-1,1-dimethyl-ethyl)-carbamic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-5-methyl-hexyl ester

Guidance literature:

With methanesulfonic acid; In methanol; for 12h; Heating;

DOI:10.1055/s-1999-3576

upstream raw materials:

(S)-2-(dibenzylamino)-4-methylpentanal

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

(2S)-N,N-dibenzylphenylalaninal

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-methyl-pentyl ester

Downstream raw materials:

(2S,3S,4S,5S)-2,5-Bis-dibenzylamino-7-methyl-1-phenyl-octane-3,4-diol

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