Technology Process of 2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate
There total 3 articles about 2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sec.-butyllithium;
1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h;
DOI:10.1248/cpb.38.2637
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / imidazole / dimethylformamide / 12 h / Ambient temperature
2: 65 percent / 1.) sec-BuLi / 1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h
With
1H-imidazole; sec.-butyllithium;
In
N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2637
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 9.14 g / 1.) NaH / 1.) THF, 30 min, room temperature, 2.) THF, 12 h, room temperature
2: 80 percent / imidazole / dimethylformamide / 12 h / Ambient temperature
3: 65 percent / 1.) sec-BuLi / 1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h
With
1H-imidazole; sec.-butyllithium; sodium hydride;
In
N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2637
