2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

Base Information

Chemical Name:2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate
CAS No.:132552-87-5
Molecular Formula:C₁₇H₃₃N₂O₃PSi
Molecular Weight:372.52
Hs Code.:

Synonyms:2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

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Chemical Property of 2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

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Technology Process of 2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

There total 3 articles about 2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 132552-70-6
3-(tert-Butyldimethylsilyloxy)phenyl tetramethylphosphorodiamidate

: 74-88-4
methyl iodide

: 132552-87-5
2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

Guidance literature:: With sec.-butyllithium; 1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h;
DOI:10.1248/cpb.38.2637

Reference yield:

: 132552-67-1
3-Hydroxyphenyl tetramethylphosphorodiamidate

: 132552-87-5
2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 65 percent / 1.) sec-BuLi / 1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h

With 1H-imidazole; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2637

Reference yield:

: 108-46-3
recorcinol

: 132552-87-5
2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N,N,N',N'-tetramethylphosphorodiamidate

Guidance literature:: Multi-step reaction with 3 steps

1: 9.14 g / 1.) NaH / 1.) THF, 30 min, room temperature, 2.) THF, 12 h, room temperature

2: 80 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 65 percent / 1.) sec-BuLi / 1.) cyclohexane, THF, -105 deg C, 1 h, 2.) cyclohexane, THF, -105 deg C, 1 h

With 1H-imidazole; sec.-butyllithium; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2637