Technology Process of 5-bromomethyl-3-(p-toluyl)-Δ2-isoxazoline
There total 4 articles about 5-bromomethyl-3-(p-toluyl)-Δ2-isoxazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert.-butylnitrite; carbon tetrabromide;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
Schlenk technique;
Inert atmosphere;
DOI:10.1039/c6ob01374k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diethyl ether / 0 - 20 °C
2: Jones reagent / diethyl ether / 1 h / 0 - 20 °C
3: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C
4: palladium diacetate; copper dichloride / dimethyl sulfoxide / 8 h / 20 °C / Inert atmosphere
With
Jones reagent; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; copper dichloride;
In
diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201403538
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Jones reagent / diethyl ether / 1 h / 0 - 20 °C
2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C
3: palladium diacetate; copper dichloride / dimethyl sulfoxide / 8 h / 20 °C / Inert atmosphere
With
Jones reagent; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; copper dichloride;
In
diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201403538
