trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one

Base Information

• Chemical Name: trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one
• CAS No.: 1610601-70-1
• Molecular Formula: C₁₄H₂₄O
• Molecular Weight: 208.344
• Mol file: 1610601-70-1.mol

Synonyms:trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one

Chemical Property of trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one

There total 2 articles about trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl (1SR,5SR)-5-(tert-butyl)-1-methyl-2-oxocyclohexane-1-carboxylate (108233-75-6,108233-76-7) → cis-(2R,4R)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (15781-34-7,15781-36-9) + trans-(2S,4R)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (15781-34-7,15781-36-9) + trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (1610601-70-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; In tetrahydrofuran; at 25 ℃; for 2h; Overall yield = 90 %; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.042

Reference yield:

allyl (1RS,5SR)-5-(tert-butyl)-1-methyl-2-oxocyclohexane-1-carboxylate (108233-75-6,108233-76-7) → cis-(2R,4R)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (15781-34-7,15781-36-9) + trans-(2S,4R)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (15781-34-7,15781-36-9) + trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (1610601-70-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; In tetrahydrofuran; at 25 ℃; for 4h; Overall yield = 93 %; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.042

Reference yield: 69.1%

trans-(2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexan-1-one (1610601-70-1) + semicarbazide hydrochloride (563-41-7) → (E)-2-((2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexylidene)hydrazine-1-carboxamide (1610601-72-3)

Guidance literature:

With pyridine; In methanol; water; at 105 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.042

upstream raw materials:

allyl (1SR,5SR)-5-(tert-butyl)-1-methyl-2-oxocyclohexane-1-carboxylate

allyl (1RS,5SR)-5-(tert-butyl)-1-methyl-2-oxocyclohexane-1-carboxylate

Downstream raw materials:

(E)-2-((2R,4S)-2-allyl-4-(tert-butyl)-2-methylcyclohexylidene)hydrazine-1-carboxamide