6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Base Information

Chemical Name:6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
CAS No.:1255339-17-3
Molecular Formula:C₂₅H₃₁F₃N₈O₂
Molecular Weight:532.569
Hs Code.:

Synonyms:6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

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Chemical Property of 6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

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Technology Process of 6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

There total 5 articles about 6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 13889-98-0
N-acetylpiperidine

: 1255340-75-0
3-(4-{1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-4-yl}phenoxy)propyl methanesulfonate

: 1255339-17-3
6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 4.5h;

Reference yield: 18.0%

: 1255340-69-2
6-{4-[4-(3-piperazin-1-ylpropoxy)phenyl]piperazin-1-yl}-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

: 64-19-7,77671-22-8
acetic acid

: 1255339-17-3
6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1043145-38-5
4-[4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]phenol

: 1255339-17-3
6-(4-{4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

1.2: 1 h / 50 °C

2.1: triethylamine / dichloromethane / 0.75 h / 0 - 5 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4.5 h / 100 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;