3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

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Chemical Name:3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole
CAS No.:1384950-43-9
Molecular Formula:C₂₃H₂₃N₅O₃S₂
Molecular Weight:481.599
Hs Code.:

Synonyms:3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

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Chemical Property of 3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

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Technology Process of 3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

There total 6 articles about 3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036461-01-4
3-cyclopropyl-5-(piperidin-4-yl)-1,2,4-oxadiazole

: 1384951-70-5
4-methanesulfonyl-7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidine

: 1384950-43-9
3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 100 ℃; for 12h;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1384950-43-9
3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / acetic acid / 12 h / 120 °C / Sealed reactor

2.1: trichlorophosphate / 3 h / 150 °C

3.1: tetrahydrofuran / 13 h / 10 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

5.2: 20 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 100 °C

With bromine; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; isopropyl alcohol;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1384950-43-9
3-cyclopropyl-5-(1-(7-(4-methanesulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 13 h / 10 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 100 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol;