3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

Base Information

Chemical Name:3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal
CAS No.:947595-05-3
Molecular Formula:C₂₆H₃₁N₃O₅
Molecular Weight:465.549
Hs Code.:

Synonyms:3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

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Chemical Property of 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

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Technology Process of 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

There total 4 articles about 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 947594-53-8
4-nitrophenacylamine ethylene ketal

: 141807-59-2
8-methyl-3S-p-tolyl-8-azabicyclo[3.2.1]octane-2S-carboxylic acid

: 947595-05-3
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1021/jm0703035

Reference yield:

: 947594-52-7
4-nitrophenacyl azide ethylene ketal

: 947595-05-3
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran / 24 h

1.2: 75 percent / water / tetrahydrofuran

2.1: 89 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 26086-61-3
2-azido-1-(4-nitrophenyl)ethan-1-one

: 947595-05-3
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 69 percent / boron trifluoride etherate / CH₂Cl₂ / 48 h / 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 24 h

2.2: 75 percent / water / tetrahydrofuran

3.1: 89 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With 1-hydroxy-7-aza-benzotriazole; boron trifluoride diethyl etherate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Staudinger reaction;
DOI:10.1021/jm0703035