3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

Base Information

Chemical Name:3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal
CAS No.:947595-06-4
Molecular Formula:C₂₆H₃₁N₃O₄S
Molecular Weight:481.616
Hs Code.:

Synonyms:3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

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Chemical Property of 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

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Technology Process of 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

There total 4 articles about 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 947595-05-3
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal

: 947595-06-4
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

Guidance literature:: 3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxamide ethylene ketal; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -45 - 0 ℃;

With hydrogen sulfide; In dichloromethane; at 0 ℃; Further stages.;
DOI:10.1021/jm0703035

Reference yield:

: 947594-52-7
4-nitrophenacyl azide ethylene ketal

: 947595-06-4
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 24 h

1.2: 75 percent / water / tetrahydrofuran

2.1: 89 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

3.1: triflic anhydride; pyridine / CH₂Cl₂ / -45 - 0 °C

3.2: 48 percent / hydrogen sulfide / CH₂Cl₂ / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 26086-61-3
2-azido-1-(4-nitrophenyl)ethan-1-one

: 947595-06-4
3β-(4-methylphenyl)tropane-2β-N-4-nitrophenacylcarboxthioamide ethylene ketal

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / boron trifluoride etherate / CH₂Cl₂ / 48 h / 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 24 h

2.2: 75 percent / water / tetrahydrofuran

3.1: 89 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

4.1: triflic anhydride; pyridine / CH₂Cl₂ / -45 - 0 °C

4.2: 48 percent / hydrogen sulfide / CH₂Cl₂ / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Staudinger reaction;
DOI:10.1021/jm0703035