3-Methylpiperidin-4-one hydrochloride

Base Information

• Chemical Name: 3-Methylpiperidin-4-one hydrochloride
• CAS No.: 4629-78-1
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.62
• Hs Code.: 2933399090
• Mol file: 4629-78-1.mol

Synonyms:4-Piperidinone,3-methyl-, hydrochloride (9CI);4-Piperidone, 3-methyl-, hydrochloride(6CI,7CI,8CI);

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Chemical Property of 3-Methylpiperidin-4-one hydrochloride

Chemical Property:

• Vapor Pressure: 0.0738mmHg at 25°C
• Melting Point: 176.5-177 °C
• Boiling Point: 224.6 °C at 760 mmHg
• Flash Point: 89.7 °C
• PSA: 29.10000
• LogP: 1.31570
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methylpiperidin-4-one hydrochloride

There total 4 articles about 3-Methylpiperidin-4-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate (17038-84-5) → 3-methylpiperidine-4-one hydrochloride (4629-78-1)

Guidance literature:

With hydrogenchloride; for 72h; Heating;

DOI:10.1016/S0223-5234(99)80046-4

Reference yield:

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate (181269-69-2) → 3-methylpiperidine-4-one hydrochloride (4629-78-1)

Guidance literature:

With hydrogenchloride; In ethanol; dichloromethane; at 0 - 25 ℃;

Reference yield:

ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate (4451-86-9) → 3-methylpiperidine-4-one hydrochloride (4629-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / NaH / 1,2-dimethoxy-ethane / 40 h / 60 °C

2: 72 percent / aq. HCl / 72 h / Heating

With hydrogenchloride; sodium hydride; In 1,2-dimethoxyethane;

DOI:10.1016/S0223-5234(99)80046-4

upstream raw materials:

ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate

ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Downstream raw materials:

methyl 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

rac-trans-3-methylpiperidin-4-ol