4451-86-9

Upstream product

• 101599-56-8 3,3'-benzoylimino-di-propionic acid diethyl ester 
• 4644-61-5 ethyl 4-piperidone-3-carboxylate hydrochloride 
• 98-88-4 benzoyl chloride 
• 55-21-0 benzamide 
• 140-88-5 ethyl acrylate 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 

Downstream Products

• 17038-84-5 ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate 
• 128988-07-8 ethyl-1-benzoyl-4-oxo-3-(2-propenyl)-3-piperidine carboxylate 
• 71766-82-0 8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane-6-carbonitrile 
• 71766-99-9 6-(1-amino-ethyl)-8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane 
• 71766-83-1 8-benzoyl-6-aminomethyl-1,4-dioxa-8-aza-spiro[4.5]decane 
• 71766-96-6 3-(8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]dec-6-yl)-3-oxo-propionic acid tert-butyl ester 
• 71766-89-7 N-(3-methyl-spiro[1,3-diaza-bicyclo[3.3.1]nonane-6,2'-[1,3]dioxolan]-2-ylidene)-toluene-4-sulfonamide 
• 71785-33-6 8-benzoyl-6-(imidazole-1-carbonyl)-1,4-dioxa-8-aza-spiro[4.5]decane 
• 71766-85-3 N-(spiro[1,3-diaza-bicyclo[3.3.1]non-2-ene-6,2'-[1,3]dioxolan]-2-yl)-toluene-4-sulfonamide 
• 71766-98-8 8-benzoyl-6-(1-hydroxyimino-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane 
• 71766-81-9 8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane-6-carboxylic acid amide 
• 71766-79-5 8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane-6-carboxylic acid 
• 71766-97-7 6-acetyl-8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane 
• 854648-68-3 3-benzyl-piperidin-4-one; hydrochloride 

Relevant academic research and scientific papers

Immunopotentiator agents

Novel compounds and methods for preparing same, immunopotentiating compositions, and a method for potentiating the immune system of a host animal. The method comprises administering to the animal an effective amount of an immunopotentiating compound of Formula I or Formula II, or a physiologically acceptable salt.

Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same

The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.

The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum

With the aim of obtaining selective ligands of the low affinity binding sites of [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine ([3H]TCP) in the rat cerebellum, oxygen and sulfur atoms were introduced in the TCP structure and derivatives to obtain analogues with a lowered lipophilicity. These compounds, and others already obtained, were assayed comparatively to determine their affinities for three sites labeled with [3H]TCP: one in the forebrain, the originally described PCP receptor, and two in the rat cerebellum. Lowering the lipophilicity and modifying the hetero-aromatic moiety yielded some ligands with increased affinity for the low affinity sites in the rat cerebellum and decreased affinity for the high affinity sites in the forebrain. Particularly, two compounds displaying both a high affinity and a good selectivity might be valuable tools to elucidate the pharmacology of the low affinity PCP sites labeled with [3H]TCP in the rat cerebellum.